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Nonclinical info are suggestive of the achievable potentiation of aspirin-relevant fetal toxicity when combined with dipyridamole (see Details). The approximated track record possibility of major birth defects and miscarriage to the indicated population is mysterious.
There may be inadequate data to determine the consequences of aspirin to the breastfed toddler and no information on the results of aspirin on milk production. The developmental and health advantages of breastfeeding should be regarded as along with the mother’s scientific have to have for AGGRENOX and any probable adverse results about the breastfed youngster from AGGRENOX or with the fundamental maternal condition.
AGGRENOX and also other medicines may possibly influence each other resulting in Unwanted side effects. AGGRENOX could have an effect on just how other medicines operate, and other medicines may well impact how AGGRENOX will work.
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Copy scientific tests with dipyridamole in mice, rabbits, and rats have disclosed no proof of hurt to the fetus approximately doses about 25 periods the most proposed daily human dose of aspirin-dipyridamole. Nonclinical knowledge are suggestive of a attainable potentiation of aspirin-associated fetal toxicity when combined with dipyridamole (see Information).
Severe heart indicators like rapidly, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and unexpected dizziness, lightheartedness, or passing out;
Diuretics The usefulness of diuretics in patients with underlying renal or cardiovascular disease might be diminished by the concomitant administration of aspirin as a consequence of inhibition of renal prostaglandins, resulting in lowered renal blood circulation and salt and fluid retention.
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Threat Summary Available knowledge from posted scientific studies and postmarketing knowledge with AGGRENOX use throughout pregnancy haven't determined a transparent Affiliation among AGGRENOX use and important beginning defects, miscarriage, or adverse maternal or fetal outcomes (see Knowledge). AGGRENOX has low-dose aspirin which can be an NSAID (see Medical Things to consider). In animal copy studies, there were adverse developmental consequences with administration of aspirin in rats and rabbits at doses about 66 and forty four occasions, respectively, the human exposure at the most recommended each day dose of aspirin-dipyridamole.
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